Перша пересадка матки
Перша пересадка матки здійснена в 1931 році в Німеччині і була зроблена Лілі Ельбі, транссексуалу, народженому як чоловік у Данії, чоловікові художниці Герди Вегенер. Ейнар Вегенер, будучи від природи жіночним, надавав послуги в якості моделі для зображення жінок. З часом Ейнар Вегенер вже не міг вийти з ролі жінки - він носив дамські одягу і гостям представлявся сестрою Герди Вегенер під ім'ям Лілі Ельбі. У підсумку він прийняв рішення змінити свою стать. З цією метою чета Вегенера переїхала до Німеччини, де Ейнару була зроблена перша в історії операція по зміні статі. Коли цей факт набув розголосу, король Данії в 1930 року розірвав шлюб Герди і Ейнара. Лілі Ельбі померла через три місяці після останньої з п'яти операцій з пересадки матки через відторгнення органу.
Перша пересадка матки від живого донора
У квітні 2000 року в Саудівській Аравії була здійснена перша пересадка матки, взятої при гістеректомії у живого донора. Через згортання крові матка була видалена через 99 днів. Звіт про операцію був опублікований в березні 2002 року в журналі International Journal of Gynaecology amp; Obstetrics.
The New York TimesFirst: A Transplant Of a UterusDENISE GRADY: March 7, 2002in Saudi Arabia are reporting that they performed the world s first uterus transplant, from a 46-year-old woman to a 26-year-old who had a hysterectomy because of a hemorrhage after childbirth, but still hoped to have another baby.transplanted uterus remained healthy for 99 days but then began to deteriorate, apparently because blood clots cut off its circulation. It had to be removed.experts were divided on the report. Some said that even though the transplant failed, the fact that it lasted 99 days was encouraging and made it an important first step toward making childbirth possible for women who have had hysterectomies or uterine abnormalities. They said uterus transplants would be temporary, and would be removed once a baby was born so that the mother could stop taking drugs to prevent the rejection of the transplanted organ, which can have serious side effects.other experts questioned the ethics of exposing a patient to the risks of a transplant for an organ that is not lifesaving.operation, performed in April 2000, was described today in the International Journal of Gynecology and Obstetrics by Dr. Wafa Fageeh, Dr. Hassan Raffa, Dr. Hussain Jabbad and Dr. Anass Marzouki, of the King Fahd Hospital and research center in Jidda, Saudi Arabia.authors said uterus transplants would be especially useful in Muslim societies, where religious authorities do not allow the use of surrogate mothers, women who volunteer to become pregnant with another woman raquo ; s child. The researchers said Islamic law does not permit genetic coding - meaning eggs or embryos - to be transferred from one person to another, but it would permit a uterus transplant.operating on people, the team practiced on 16 baboons and 2 goats. They said the operation is technically difficult because the blood vessels that have to be sewn together are tiny, much smaller than those in other organ transplants.26-year-old recipient had undergone a hysterectomy six years earlier but still wanted another baby. The donor, 46, needed surgery for ovarian cysts and agreed to give her uterus to the younger woman.recipient took anti-rejection drugs before and after the surgery, as well as hormones to help the uterus develop a normal lining. All went well until the 99th day, when she had pelvic discomfort, and tests showed that blood flow to the uterus had stopped. A hysterectomy was done.doctors wrote that the problem may have occurred because the uterus was not anchored securely enough, leading to probable tension, torsion, or kinking of blood vessels .. Fageeh said her team had not performed any more uterus transplants, but we are planning to do so and there are many women who want that surgery. an editorial accompanying the case report, Dr. Louis G. Keith of Northwestern University and Dr. Giuseppe Del Priore of New York University said that the case should not be considered a failure, and that reproductive organs are a new frontier in transplant surgery. For some people, they wrote, childbearing is the greatest event of a lifetime, and a uterus transplant would not be considered frivolous or unnecessary. raquo ;. Del Priore said he and his colleagues had been experimenting with uterus transplants in pigs and rats for almost two years. He said that although the transplants survived and functioned for several months in the pigs, producing normal menstrual cycles, the animals were unable to become pregnant, and the researchers do not know why.he said the scientists were learning from their mistakes and would eventually develop a reliable technique for people.
